Download ADME and Translational Pharmacokinetics / Pharmacodynamics by Honghui Zhou, Frank-Peter Theil PDF

By Honghui Zhou, Frank-Peter Theil

With an emphasis at the basic and useful elements of ADME for healing proteins, this ebook is helping readers strategize, plan and enforce translational learn for biologic drugs.

• Details state-of-the-art ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with useful elements of ADME in biologic drug discovery and improvement and compares innovator biologics with biosimilar biologics and small molecules with biologics,  giving a lessons-learned viewpoint
• Includes case stories approximately leveraging ADME to enhance biologics drug improvement for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectancies and views for constructing biologic medicines in united states, european, and Japan
• Provides mechanistic perception into biodistribution and target-driven pharmacokinetics in very important websites of motion corresponding to tumors and the brain

Show description

Read Online or Download ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development PDF

Best industrial & technical books

Microemulsions: Background, New Concepts, Applications, Perspectives

Even if first defined by means of Winsor in 1954, the chemistry and expertise of microemulsions draws huge study curiosity. till particularly lately, microemulsions weren't utilized in huge scale purposes as their section behaviour and microstructure weren't good understood and massive quantities of surfactant have been wanted for his or her formula.

Protein Purification. From Molecular Mechanisms to Large-Scale Processes

Content material: Large-scale protein purification : advent / Richard C. Willson and Michael R. Ladisch -- suggestions for large-scale protein purification / Sa V. Ho -- Separations in biotechnology : the main function of adsorptive separations / E. N. Lightfoot -- Peptide and protein partitioning in aqueous two-phase structures : influence of amino acid series / Alan D.

Stimuli Responsive Drug Delivery Systems : From Introduction to Application

Stimuli responsive drug supply platforms have emerged as some of the most leading edge periods of polymer fabrics of recent fabrics technology. The polymer architectures displaying a wide swap of their physico chemical behaviors according to minor indications from the environments have fabricated almost certainly priceless fabrics for pharmaceutical and biomedical functions.

Environmental transport phenomena

"This ebook provides the topic of delivery phenomena beginning with the basic rules and mechanisms that govern mass delivery, and carrying on with with the formula and answer of sensible difficulties spanning all sub-disciplines of environmental technological know-how and chemical engineering. The publication offers the reader with a primary realizing of the way to quantify the unfold and distribution of contaminants within the setting, in addition to the root for designing approaches concerning water purification, wastewater remedy, and reliable waste disposal, between others.

Extra info for ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development

Example text

Com/special‐ reports/10‐best‐selling‐drugs‐2013. Accessed 2015 Jun 3. [6] Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE. The Protein Data Bank. Nucleic Acids Res 2000;28:235–242. [7] Kunkel TA. Rapid and efficient site‐directed mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A 1985;82:488–492. [8] Wells JA, Vasser M, Powers DB. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites. Gene 1985;34:315–323.

Quantitative high‐throughput analysis of drugs in biological matrices by mass spectrometry. Mass Spectrom Rev 2003;22:195–214. [24] Korfmacher WA. Principles and applications of LC‐MS in new drug discovery. Drug Discov Today 2005;10:1357–1367. [25] Castro‐Perez J, Plumb R, Granger JH, Beattie L, Joncour K, Wright A. Increasing throughput and information content for in vitro drug metabolism experiments using ultra‐ performance liquid chromatography coupled to a quadrupole time‐of‐flight mass spectrometer.

In this way, the molecule can “piggy‐back” to albumin to achieve antibody‐ like serum retention without any of the properties of the Fc. Another solution is to use PEGylation. Certolizumab pegol consists of a Fab′ fragment engineered to have a single free cysteine in its hinge region to which a PEG moiety is site‐ specifically conjugated. The PEG moiety is thought to create a large hydrodynamic water shell around the Fab fragment, which prevents kidney filtration and may reduce its tendency to diffuse out of normal blood but results in efficient tissue penetration at sites of inflammation [86].

Download PDF sample

Rated 4.73 of 5 – based on 38 votes