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By Wei Li, Xumu Zhang

Each assessment in the quantity seriously surveys one element of that subject and locations it in the context of the quantity as a complete. the main major advancements of the final five to ten years are offered utilizing chosen examples to demonstrate the foundations mentioned. The assurance isn't really meant to be an exhaustive precis of the sphere or comprise huge amounts of knowledge, yet should still otherwise be conceptual, focusing on the methodological considering that may permit the non-specialist reader to appreciate the knowledge provided. Contributions additionally provide an outlook on power destiny advancements within the field.

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References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Charette (*) and V. B. Charette and V. Lindsay Fig. 1 Most common approaches to α-chiral amines 1 Introduction The ubiquity of α-chiral amines in bioactive molecules and natural products has been a constant source of inspiration for the development of new and more effective methods for their formation. Various approaches to α-chiral amines are shown in Fig.

B. Charette (*) and V. B. Charette and V. Lindsay Fig. 1 Most common approaches to α-chiral amines 1 Introduction The ubiquity of α-chiral amines in bioactive molecules and natural products has been a constant source of inspiration for the development of new and more effective methods for their formation. Various approaches to α-chiral amines are shown in Fig. 1. Common approaches to generate α-chiral amines include imine reduction [1] and Strecker [2] and Mannich type (aza-Henry) reactions [3, 4].

Friestad 23. Friestad GK (2010) In: Nugent T (ed) Chiral amine synthesis. Methods, developments and applications. Wiley-VCH, Weinheim, pp 51–74 24. Miyabe H, Yoshioka E, Kohtani S (2010) Curr Org Chem 14:1254–1264 25. Friestad GK (2001) Tetrahedron 57:5461–5496 26. Friestad GK (2005) Eur J Org Chem 3157–3172 27. Fallis AG, Brinza IM (1997) Tetrahedron 53:17543–17594 28. Nishiyama H, Kitajima T, Matsumoto M, Itoh K (1984) J Org Chem 49:2298–2300 29. Stork G, Kahn M (1985) J Am Chem Soc 107:500–501 30.

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